119 Szczepanowska_Layout 1
نویسندگان
چکیده
Contemporary cognitive science attempts to provide computational models that describe how consciousness and emotion constitute adaptive behavior. Given the recent neurobiological view that highlights the fact that the cognitive and emotional regions of the brain work together to achieve conscious behavior, it was shown that signal-detection theory (SDT) can effectively capture the notion of the consciousness–emotion interactions that underlie emotional experience. In particular, I have demonstrated that the hierarchical SDT model is capable of estimating different levels of the hierarchical organization of emotional experience. I have also shown that the threshold SDT model predicts that the formation of emotion experience requires a discrete decision space, which implies that the neural representations of emotion are mediated by thresholds to be experienced consciously. The application of both computational SDT models seems to be a promising advance for studying consciousness–emotion interactions.
منابع مشابه
NY-ESO-1 119-143 is a promiscuous major histocompatibility complex class II T-helper epitope recognized by Th1- and Th2-type tumor-reactive CD4+ T cells.
The NY-ESO-1 gene product is expressed by a range of human tumors and is recognized by antibodies from sera of cancer patients with NY-ESO-1-expressing tumors. The NY-ESO-1 gene also encodes several MHC class I- and MHC class II-restricted tumor epitopes recognized by T lymphocytes. In particular, we previously reported that the NY-ESO-1 119-143 peptide contains at least two HLA-DRB1*0401-prese...
متن کاملAssessment of vaccine-induced CD4 T cell responses to the 119-143 immunodominant region of the tumor-specific antigen NY-ESO-1 using DRB1*0101 tetramers.
PURPOSE NY-ESO-1 (ESO), a tumor-specific antigen of the cancer/testis group, is presently viewed as an important model antigen for the development of generic anticancer vaccines. The ESO(119-143) region is immunodominant following immunization with a recombinant ESO vaccine. In this study, we generated DRB1*0101/ESO(119-143) tetramers and used them to assess CD4 T-cell responses in vaccinated p...
متن کاملAntibodies that Inhibit Malaria Merozoite Surface Protein–1 Processing and Erythrocyte Invasion Are Blocked by Naturally Acquired Human Antibodies
Merozoite surface protein-1 (MSP-1) of the human malaria parasite Plasmodium falciparum undergoes at least two endoproteolytic cleavage events during merozoite maturation and release, and erythrocyte invasion. We have previously demonstrated that mAbs which inhibit erythrocyte invasion and are specific for epitopes within a membrane-proximal, COOH-terminal domain of MSP-1 (MSP-119) prevent the ...
متن کاملA Bibliography of the ACM Turing Awards (1966–date)
A. [111, 81]. Abstraction [45]. ACM [122, 120, 83, 91, 123, 82, 90, 115, 119, 70, 113, 95]. Agenda [113]. Alan [118, 103]. Algebra [11, 25]. Algorithm [62, 63]. Algorithmic [1, 92, 52]. Analyst [5, 67]. annual [122]. approaches [97]. Architecture [110, 119, 113]. arithmetic [72]. Art [8, 44]. artificial [46, 47]. Assessing [26, 91]. August [122]. authorship [111]. Award [120, 83, 69, 12, 82, 79...
متن کاملThe role of phenylalanine-119 of the reverse transcriptase of mouse mammary tumour virus in DNA synthesis, ribose selection and drug resistance.
Phe-119 in the reverse transcriptase (RT) of mouse mammary tumour virus (MMTV) is homologous with Tyr-115 in HIV type 1 (HIV-1) RT and to Phe-155 in murine leukaemia virus (MLV) RT. By mutating these residues in HIV-1 and MLV RTs (which are strict DNA polymerases) the enzymes were shown to function also as RNA polymerases. Owing to the uniqueness of MMTV as a type B retrovirus, we have generate...
متن کامل